Covidyte™ TF670

CAT N°: 33766
Price:

641.00 544.85

Viral main protease (Mpro), also known as 3C-like protease (3CLpro), is a viral protease that mediates the replication and transcription of severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2, the causative agents of SARS and COVID-19, respectively.{54840,54841} Mpro digests SARS-CoV and SARS-CoV-2 viral polyproteins at 11 conserved sites, beginning with autolytic cleavage of itself, to release the functional peptides required for viral replication and transcription. Covidyte™ TF670 is a fluorogenic substrate for Mpro that contains 14 amino acids, KTSAVLQSGFRKME, which are recognized by Mpro. Upon enzymatic cleavage by Mpro, the fluorophore, TideFluor™ 5 (TF5), is separated from the quencher, TideQuencher™ 5 (TQ5), displays excitation/emission maxima of 640/680 nm, respectively, and can be used to quantify Mpro activity.

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