€680.00 €578.00
Choline acetyltransferase (ChAT) is an acyltransferase that catalyzes the synthesis of acetylcholine from acetyl coenzyme A (acetyl-CoA; Item No. 16160) and choline.{55140} It is composed of a catalytic domain flanked on both sides by a substrate binding domain.{55140,55145} ChAT is synthesized in the soma of cholinergic neurons in the central and peripheral nervous system and is transported to nerve terminals where it exists in a soluble form or on synaptic vesicles in a membrane-bound form.{55140} It is used as a marker of cholinergic neurons.{55141} Genome-wide deletion of Chat in mice is perinatal lethal.{55142} Intracerebroventricular transplantation of human HB1.F3 neural stem cells overexpressing CHAT reverses learning and memory deficits in a mouse model of Alzheimer’s disease induced by kainic acid (Item No. 78050).{55143} ChAT activity is reduced in a number of neurodegenerative disorders, including Alzheimer’s disease, amyotrophic lateral sclerosis (ALS), and Huntington’s disease.{55140} SNPs in CHAT are associated with Alzheimer’s disease in humans.{55144} Cayman’s Choline Acetyltransferase Polyclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications. The antibody recognizes ChAT at approximately 70 kDa from human, avian, chicken, guinea pig, mouse, non-human primate, and rat samples.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 100 µl |
|---|---|
| Shipping | dry ice |
| Molecular weight | 0 |
| Host | Goat |
| Antigen | Recombinant human choline acetyltransferase |
| Application(s) | IHC, WB |
| Formulation | 100 µl affinity-purified polyclonal antibody |
| Custom code | 3822.19 |
| UNSPSC code | 12352203 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009
Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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