Erdosteine

Erdosteine

CAT N°: 29177
Price:

182.00

Erdosteine is a mucolytic agent and an antioxidant.{47790,47791,47792} It inhibits LPS-induced I?B kinase (IKK) activity, NF-?B-mediated transcription, and production of IL-6 and IL-1? in RAW 264.7 cells.{47790} Erdosteine (7.5 mg/kg) prevents depletion of renal catalase and glutathione peroxidase (GPX) and increases in renal malondialdehyde (MDA) and nitric oxide (NO) levels in a rat model of nephrotoxicity induced by cisplatin (Item No. 13119).{47791} It reduces spinal cord lipid peroxidation and destruction of spinal motor neurons in a rabbit model of spinal cord ischemia and reperfusion injury induced by thoracoabdominal aortic clamping. Erdosteine (150 mg/kg) reduces lung weight, MDA and protein carbonyl levels, and macrophage and neutrophil accumulation in a mouse model of acute lung injury induced by oleic acid (Item Nos. 90260 | 24659).{47792} Formulations containing erdosteine have been used in the treatment of chronic obstructive pulmonary disease (COPD).

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