SHA-<wbr/>68

SHA-68

CAT N°: 21512
Price:

48.00

SHA-68 is an antagonist of the neuropeptide S receptor (NPSR; IC50s = 22 and 23.8 nM for the NPSR Asn107 and NPSR Ile107 isoforms, respectively).{37267} It is selective for NPSR over a panel of 14 G protein-coupled receptors exhibiting no activity at a concentration of 10 ?M. SHA-68 (50 mg/kg) reduces NPS-induced horizontal activity and vertical rearing and climbing in mice. SHA-68 also reduces conditioned reinstatement of cocaine seeking in rats.{37268}

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