SR 59230A (hydro<wbr/>chloride)

SR 59230A (hydrochloride)

CAT N°: 21407
Price:

55.00

SR 59230A (hydrochloride) is a ?3-adrenergic receptor (?3-AR) antagonist (pA2s = 8.76, 7.31, and 6.63 in rat proximal colon, guinea pig atrium, and guinea pig trachea, respectively).{34206} It is less selective for ?3-AR in cells transfected with the human ?-AR subtypes (Kis = 16.4, 61.9, and 122 nM for ?1-, ?2-, and ?3-AR, respectively).{34205} At low concentrations, SR 59230A blocks MDMA-induced hyperthermia, while at high concentrations it blocks hyperthermia but also increases heat loss through an ?1-AR antagonistic mechanism.{34203} In adipocytes, it induces phosphorylation of p38 MAPK via the Gs pathway.{34207} It has also been used in studies of heart failure to elucidate the role of the ?3-ARs.{34204}

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