Triacsin C

Triacsin C

CAT N°: 10007448
Price:

433.00

Triacsin C, originally isolated from Streptomyces sp., is an inhibitor of long fatty acid acyl-CoA synthetase (IC50 = 6.3 ?M in Raji cells).{1627} It has been shown to interfere with lipid metabolism by inhibiting the de novo synthesis of triglycerides, diglycerides, and cholesterol esters.{25053} It is also known to act as a hypotensive vasodilator, modulating endothelial nitric oxide synthase repalmitoylation by limiting palmitoyl CoA availability.{25054} Triacsin C can inhibit pancreatic ?-cell function by suppressing the mobilization of intracellular calcium.{25055}

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