Trimidox (hydro<wbr>chloride)

Trimidox (hydrochloride)

CAT N°: 10011124
Price:

95.00

Ribonucleotide reductase, the rate-limiting enzyme for de novo DNA synthesis, is a common target for chemotherapy. Its increased activity in cancer cells is associated with malignant transformation and proliferation.{14245} Trimidox is a specific ribonucleotide reductase inhibitor that reduces levels of dGTP and dCTP in HL-60 cells, inducing apoptosis via activation of caspases without altering the cell cycle distribution.{14245,15318} Trimidox inhibits growth of human promyelocytic leukemia HL-60 cells with an IC50 value of 35 µM.{14245}

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