Y-26763

Y-26763

CAT N°: 21459
Price:

55.00

Y-26763 is an activator of ATP-sensitive potassium (KATP) channels.{50363} It increases the frequency of KATP channel openings in the presence of ATP and activates KATP channel currents in isolated human ?-cells when used at a concentration of 200 ?M. It also inhibits increases in intracellular calcium induced by histamine or norepinephrine (Item No. 16673) in isolated rabbit mesenteric artery smooth muscle in a concentration-dependent manner.{50364} Y-26763 induces relaxation in isolated precontracted rat aortic rings (IC50 = 0.027 ?M).{50365} It decreases mean blood pressure in spontaneously hypertensive rats when administered intravenously at a dose of 0.03 mg/kg, an effect that can be reversed by glibenclamide (Item No. 15009).

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